1,2,3,4,12,13,29 https://aaoinfo.org/whats-trending/when-should-your-child-see-an-orthodontist/

5,14,15,16,17 https://www.chop.edu/treatments/phase-1-orthodontics

6,8,9,10,18 https://aaoinfo.org/whats-trending/when-should-my-child-see-an-orthodontist-age-7/

https://www.webmd.com/oral-health/children-and-orthodontics

11 https://www.healthline.com/health/dental-and-oral-health/resorption#bottom-line

19 Based on the survey in US and CAN in February 2021. Invisalign orthodontists were surveyed whose patients used Invisalign Stickables during the limited market release in US and CAN responded to the question: “Please indicate your agreement with the following statement: Offering Invisalign Stickables provides a personalized Invisalign First treatment experience for younger phase 1 patients.” Agreement scale is 1-4 with 1 being “strongly agree” and 4 being “strongly disagree”.

20,24,26,28 n a study by Miller et al, with adults measuring pain in the first week of treatment. Kevin Miller et al.  “A comparison of treatment impacts between Invisalign aligner and fixed appliance therapy during the first week of treatment.”  American Journal of Orthodontics and Dentofacial Orthopedics.  Volume 131, Issue 3, pp. 302. e1-302.e9, March 2007.

21 https://www.stanfordchildrens.org/en/topic/default?id=anatomy-and-development-of-the-mouth-and-teeth-90-P01872

22,23 https://aaoinfo.org/whats-trending/6-facts-about-two-phase-treatment/

25 Based on the global survey in December 2020 to March 2021 in NA, EMEA and APAC regions which included the following countries: USA, Canada, France, Italy, Spain, Brazil, Australia, China, Japan, 224 Invisalign orthodontists responded to the question: “Please indicate your agreement with the following statement: Invisalign First treatment is not as painful* for Phase 1 patients as traditional functional appliances”. Agreement scale is 1-4 with 1 being “strongly disagree” and 4 being “strongly agree”

27 Data on File at Align Technology, as of April 26, 2018

30 Compared to Invisalign aligners previously made from single-layer (EX30) material.

31 Buschang et al; Comparative time efficiency of aligner therapy and conventional edgewise braces. Angle Orthod 1 May 2014; 84 (3): 391–396. Borda et al; Outcome assessment of orthodontic clear aligner vs fixed appliance treatment in a teenage population with mild malocclusions. Angle Orthod 1 July 2020; 90 (4): 485–490.